Presynaptic Membrane Retrieval and Endosome Biology: Defining Molecularly Heterogeneous Synaptic Vesicles
نویسندگان
چکیده
منابع مشابه
Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesicles.
The release and uptake of neurotransmitters by synaptic vesicles is a tightly controlled process that occurs in response to diverse stimuli at morphologically disparate synapses. To meet these architectural and functional synaptic demands, it follows that there should be diversity in the mechanisms that control their secretion and retrieval and possibly in the composition of synaptic vesicles w...
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The function of the nervous system depends on the exocytotic release of neurotransmitter from synaptic vesicles (SVs). To sustain neurotransmission, SV membranes need to be retrieved, and SVs have to be reformed locally within presynaptic nerve terminals. In spite of more than 40 years of research, the mechanisms underlying presynaptic membrane retrieval and SV recycling remain controversial. H...
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The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that are differentially poised for exocytosis shapes short-term plasticity. However, the frequency-dependent mobilization of these sub-pools is poorly understood. Using slice recordings and modeling of synaptic activity at cerebellar granule cell to Purkinje cell synapses of mice, we describe two sub-pools in...
متن کاملTitle: A frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity
Frédéric Doussau, Hartmut Schmidt, Kevin Dorgans, Antoine M. Valera, Bernard Poulain, and Philippe Isope. Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, Université de Strasbourg, 67084 Strasbourg, France Carl-Ludwig Institute for Physiology, University of Leipzig, 04103 Leipzig, Germany Present Address: Department of Neuroscience, Physiology and Pharmacology, University ...
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Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance. In classical models of synaptic function these vesicle pools are synapse-specific, but accumulating evidence is now demonstrating that some vesicles are laterally mobile along axons and readi...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2013
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a016915